Journal
CLINICAL CHEMISTRY
Volume 51, Issue 7, Pages 1185-1191Publisher
OXFORD UNIV PRESS INC
DOI: 10.1373/clinchem.2004.045872
Keywords
-
Categories
Funding
- NHLBI NIH HHS [N01-HC-48050, N01-HC-48049, N01-HC-48048, R01 HL053560, N01-HC-48047, R01-HL-53560, N01-HC-95095] Funding Source: Medline
Ask authors/readers for more resources
Background: We hypothesized that serum gamma-glutamyltransferase (GGT) would positively predict the risk of microalbuminuria, a frequent consequence of both diabetes and hypertension, because serum GGT predicted diabetes and hypertension in dose-response relationships. Methods: In this prospective study, 2478 black and white men and women without microalbuminuria at year 10 provided urine samples 5 years later. Year 10 GGT cutpoints were 12, 18, and 29 U/L. Results: The incidence of microalbuminuria across year 10 GGT categories was U-shaped. Adjusted odds ratios across quartiles of serum GGT were 1.0, 0.39, 0.54, and 0.94 (P < 0.01 for quadratic term), but the shape of association depended on the status of hypertension or diabetes (P < 0.01 for interaction). Among individuals who ever had hypertension or diabetes, year 10 serum GGT showed a clear positive dose-response association with incident microalbuminuria (P < 0.01 for trend), whereas among individuals with neither hypertension nor diabetes during the study, year 10 GGT showed a U-shaped association with it (P < 0.01 for quadratic term). When the long-term risk was evaluated in 3895 participants based on serum GGT at year 0 and prevalence of microalbuminuria at year 10 or year 15, the trends were similar but weaker than those of short-term incidence risk. Conclusions: Serum GGT within the physiologic range predicted microalbuminuria among patients with hypertension or diabetes and may act as a predictor of microvascular and/or renal complications in these vulnerable groups. GGT showed a U-shaped association with microalbuminuria among persons who did not develop either hypertension or diabetes. (c) 2005 American Association for Clinical Chemistry.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available