Journal
COMPTES RENDUS BIOLOGIES
Volume 328, Issue 7, Pages 616-631Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.crvi.2005.05.002
Keywords
apoptosis; mitochondria; permeabilization; Bax; Bcl-2; lipids; cardiolipin
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In many apoptotic responses, pro-apoptotic members of the Bcl-2 family trigger the permeabilization of the outer mitochondrial membrane, thereby allowing the release of mitochondrial apoptogenic factors that contribute to caspase activation in the cytosol. The mechanisms that lead to the activation of pro-apoptotic Bcl-2 family members and to the permeabilization of the outer mitochondrial membrane are not yet completely understood. Here, we attempt to summarize our current view of the mechanisms that lead to these events, regarding both additional proteins that were recently suggested to be involved, and the roles of lipids. (c) 2005 Academie des sciences. Published by Elsevier SAS. All rights reserved.
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