Journal
AMERICAN JOURNAL OF CLINICAL NUTRITION
Volume 82, Issue 1, Pages 215S-217SPublisher
OXFORD UNIV PRESS
DOI: 10.1093/ajcn/82.1.215S
Keywords
obesity; genetics; association study; candidate genes; single nucleotide polymorphism; complex trait
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Funding
- NIDDK NIH HHS [K23 DK067288-01] Funding Source: Medline
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The obesity epidemic is attributable to dietary and behavioral trends acting on a person's genetic makeup to determine body mass and susceptibility to obesity-related disease. Common forms of obesity have a strong hereditary component, yet genetic pathways that contribute to obesity have not yet been elucidated. Many genetic association studies have been reported, but few have been successfully replicated. New research tools and large studies will lead to an understanding of genes and their interaction to cause obesity, which may help guide successful interventions and treatments.
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