Journal
FITOTERAPIA
Volume 76, Issue 5, Pages 462-465Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2005.03.004
Keywords
acaciaside A and B; antifungal; antibacterial; phosphofructokinase; isocitrate dehydrogenase
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Acaciaside A and B, two acylated bisglycoside saponins originally isolated from the funicles of Acacia auriculiformis, are known to have antihelminthic activity. Their antifungal and antibacterial activities were investigated. Complete inhibition of conidial germination of Aspergillus ochraceous and Curvularia lunata was recorded at 300 mu g/ml or less whereas to inhibit the growth of Bacillus megaterium, Salmonella typhimurium and Pseudomonas aeruginosa 700 mu g/ml or higher concentrations of the mixture was required. Two catabolic enzymes, phosphofructokinase and isocitrate dehydrogenase, responded differentially in fungi and bacteria against sublethal concentrations of the compound when assayed from their cell free extracts. An increased specific activity of the enzymes in bacteria and a decrease activity in fungi indicate a possible different mechanism of inhibition of saponins on the organisms tested. (c) 2005 Elsevier B.V. All rights reserved.
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