Journal
JOURNAL OF NEUROIMMUNOLOGY
Volume 164, Issue 1-2, Pages 37-47Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2005.03.013
Keywords
astrocytes; HHV-6; cytokines; gene profiling; inflammation
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Human herpesvirus-6A (HHV-6A) is a common pathogen whose role in CNS disorders including multiple sclerosis remains controversial. To understand how HHV-6A could influence inflammatory pathways in the CNS, we infected cultured human adult astrocytes and examined the expression of 268 cytokines, chemokines, growth factors and their receptors by gene profiling. HHV-6 infection alone had little effect on the astrocyte gene profile but strongly altered the astrocyte response to proinflammatory cytokines. Under those conditions astrocytes express higher levels of anti-inflmmatory mediators including IL-10 and IL-11, chemotactic factors, growth factors and factors controlling type I interferon production. Our data suggest that HHV-6 itself does not evoke a proinflammatory response in astrocytes but rather triggers immune modulatory factors in the face of inflammation. (C) 2005 Elsevier B.V. All rights reserved.
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