4.4 Article

Imaging of photodynamically generated singlet oxygen luminescence in vivo

Journal

PHOTOCHEMISTRY AND PHOTOBIOLOGY
Volume 81, Issue 4, Pages 941-943

Publisher

WILEY-BLACKWELL
DOI: 10.1562/2005-03-15-TSN-462R.1

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We describe a novel scanning-laser system for imaging type-II photodynamically generated singlet oxygen (O-1(2)[(1)Delta(g)]) luminescence and demonstrate it in vivo in an intradermal tumor model in mice. We verify the strong oxygen-dependence of the signal and show that the images are near the practical resolution limit.

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