Journal
DEVELOPMENTAL DYNAMICS
Volume 233, Issue 3, Pages 1038-1044Publisher
WILEY
DOI: 10.1002/dvdy.20378
Keywords
proprotein convertase; embryogenesis; Xenopus; furin; PC6; PC4
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Funding
- NHLBI NIH HHS [T32HL007781] Funding Source: Medline
- NICHD NIH HHS [R01HD37976, R01HD42598] Funding Source: Medline
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Proprotein convertases (PCs) are a family of serine endoproteases that protcolytically activate many precursor proteins within various secretory pathway compartments. Loss-of-function studies have demonstrated a critical role for these proteases in embryonic patterning and adult homeostasis, yet little is known about how substrate selectivity is achieved. We have identified Xenopus orthologs of three PCs: furin, PC6, and PC4. In addition to previously described isoforms of PC6 and furin, four novel splice isoforms of PC6, which are predicted to encode constitutively secreted proteases, and a putative transmembrane isoform of PC4 were identified. Furin and PC6 are expressed in dynamic, tissue-specific patterns throughout embryogenesis, whereas PC4 transcripts are restricted primarily to germ cells and brain in adult frogs. (c) 2005 Wiley-Liss, Inc.
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