Journal
JOURNAL OF NEUROSURGERY
Volume 103, Issue 1, Pages 97-103Publisher
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/jns.2005.103.1.0097
Keywords
cerebral hemorrhage; brain edema; sex difference; estrogen receptor; rat
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Funding
- NINDS NIH HHS [NS-039866, NS-047245, NS-17760] Funding Source: Medline
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Object. The aims of this study were to determine the following: whether there are sex differences in intracerebral hemorrhage (ICH) induced brain injury in rats, whether delayed administration of 17 beta-estradiol can reduce ICH-induced brain damage, and whether these effects are estrogen receptor (ER)-dependent. Methods. Male and female Sprague-Dawley rats received an infusion of 100 mu l autologous whole blood into the right basal ganglia. Twenty-four hours later the rats were killed. The effects of 17 beta-estradiol on ICH-induced brain injury were examined by measuring brain edema and neurological deficits. Both ER-alpha and hemeoxygenase (HO)-1 were investigated through Western blot and immunohistochemical analysis. Brain edema was significantly less severe in female compared with that in male rats. The ER antagonist ICI 182,780 exacerbated ICH-induced brain edema in female but not in male rats, indicating that ER-alpha activation during ICH is protective in female rats. Administration of exogenous 17 beta-estradiol in male, but not in female, rats significantly attenuated brain edema, neurological deficits, and ICH-induced changes in HO-1 when given 2 hours after hemorrhage. The effects of exogenous 17 beta-estradiol occurred through an ER-independent mechanism. Conclusions. Results in this study indicate that 17 beta-estradiol could be a potential therapeutic agent for ICH.
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