Journal
CANCER RESEARCH
Volume 65, Issue 13, Pages 5485-5487Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-05-1453
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Emerging evidence suggests that the proapoptotic kinase mammalian sterile 20-like kinase 2 (MST2) acts in a novel tumor suppression pathway. Recently, we showed that Raf-I kinase sequesters and inhibits MST2 and that this event is critical for Raf-mediated cell survival. In this review, we summarize Raf control of MST2 and we outline a novel pathway involving the downstream effector proteins Salvador and Warts/Lats that may act to limit the positive effects of Raf-mitogen-activated protein kinase signaling in cancer cells.
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