Journal
NATURE NEUROSCIENCE
Volume 8, Issue 7, Pages 853-854Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1476
Keywords
-
Categories
Funding
- NINDS NIH HHS [NS27037, NS47773] Funding Source: Medline
Ask authors/readers for more resources
GluR1 and GluR2 subunits compose AMPA receptors (AMPARs) in the mature hippocampus, and both the GluR1 subunit and Ca2+/calmodulin-dependent protein kinase II (CaMKII) are required for synaptic plasticity, memory and learning. Although GluR1 phosphorylation by CaMKII is preserved, the functional regulation of AMPARs by phosphorylation is lost in the presence of the GluR2 subunit. Our findings define a previously unknown, dominant role of the GluR2 subunit in signaling mediated by CaMKII at AMPARs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available