Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 192, Issue 1, Pages 129-135Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/431365
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Funding
- NCRR NIH HHS [RR 00166, P51 RR000166] Funding Source: Medline
- NIAID NIH HHS [AI-40307-02] Funding Source: Medline
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We inoculated 45 female macaques in the cervix with Chlamydia trachomatis once weekly for 5 weeks and randomly assigned them to treatment with doxycycline (n = 12), azithromycin (n = 12), or placebo (n = 21). At hysterectomy, cervical cultures remained positive in 12 of 21 placebo-treated monkeys, versus 0 of 12 21 doxycycline- or azithromycin-treated monkeys (P < .01); cervical ligase chain reaction remained positive in 15 placebo-, 1 doxycycline-, and 0 azithromycin-treated monkeys. Tubal swabs remained positive in 3 placebo-, 1 doxycycline-, and 0 azithromycin-treated monkeys. Immunopathologic damage was moderate to widespread in upper and lower reproductive-tract tissues from placebo- and doxycycline- treated monkeys but were significantly reduced in azithromycin-treated monkeys. Transforming growth factor-beta was also significantly less prevalent in azithromycin-treated monkeys. Azithromycin treatment dramatically reduced the inflammatory response and was highly effective in eradicating C. trachomatis from the lower and upper reproductive tract (12/12), compared with doxycycline (7/12) and placebo (3/21).
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