Journal
NEUROBIOLOGY OF AGING
Volume 26, Issue 7, Pages 995-1000Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2004.09.014
Keywords
caloric restriction; AD transgenics; amyloid deposition; astrocyte activation
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Dietary influences on Alzheimer disease (AD) are gaining recognition. Because many aging processes are attenuated in laboratory mammals by caloric restriction (CR), we examined the effects of short-term CR in two AD-transgenic mice, APP(swe/ind) (J20) and APP(swe) + PS1(M146L) (APP+PS1), CR substantially decreased the accumulation of A beta-plaques in both lines: by 40% in APP(swe/ind) (CR, 6 weeks), and by 55% in APP + PS1 (CR, 14 weeks). CR also decreased astrocytic activation (GFAP immunoreactivity). These influences of CR on AD-transgenic mice are consistent with epidemiological reports that show that high caloric diets associate with the risk of AD, and suggest that dietary interventions in adult life might slow disease progression. (c) 2004 Elsevier Inc. All rights reserved.
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