Journal
ARCHIVES OF TOXICOLOGY
Volume 79, Issue 7, Pages 422-426Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00204-004-0645-1
Keywords
Prorocentrum lima; marine toxins; mussel; micronucleus; Perna perna; DSP toxins
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Micronucleus (MN) and other nuclear abnormalities have been measured in the hemocytes of mussels Perna perna to verify whether feeding mussels with different concentrations of Prorocentrum lima results in accumulation of levels of okadaic acid (OA) capable of inducing genotoxic effects at the chromosome level, as evidenced by micronuclei and nuclear abnormalities. Four groups of 12 mussels housed individually in aquaria containing filtered seawater were fed with different concentrations of P. lima. Another group collected directly from the production area served as outdoor control. A significantly higher frequency of MN and nuclear lesions was observed in hemocytes from the groups fed P. lima.
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