Journal
OPTICS LETTERS
Volume 30, Issue 13, Pages 1677-1679Publisher
OPTICAL SOC AMER
DOI: 10.1364/OL.30.001677
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- NIBIB NIH HHS [R01 EB00763] Funding Source: Medline
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The optoacoustic technique is noninvasive, has high spatial resolution, and potentially can be used to measure the total hemoglobin concentration ([THb]) continuously and accurately. We performed in vitro measurements in blood and in vivo tests in healthy volunteers. Our clinical protocol included rapid infusion of intravenous saline to simulate rapid change in the [THb] during fluid therapy or surgery. Optoacoustic measurements were made from the wrist area overlying the radial artery for more than 1 h. The amplitude of the optoacoustic signal generated in the radial artery closely followed the [THb] measured directly in concurrently collected blood samples. (c) 2005 Optical Society of America.
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