Journal
INFECTION AND IMMUNITY
Volume 73, Issue 7, Pages 4410-4413Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.73.7.4410-4413.2005
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Funding
- NIAID NIH HHS [R01 AI045153, R01 AI045153-12, R01 AI045153-09, R01 AI045153-11, R01 AI045153-08A1, R01 AI045153-10, AI-45153] Funding Source: Medline
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We have previously shown that phosphatidylinositol-specific phospholipase C (PI-PLC) produced by Listeria monocytogenes activates a host protein kinase C (PKC) cascade which promotes escape of the bacterium from a macrophage-like cell phagosome. Here, we provide evidence linking bacterial PI-PLC and host PKC beta to phagosome permeabilization, which precedes escape.
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