Journal
JOURNAL OF IMMUNOLOGY
Volume 175, Issue 1, Pages 196-200Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.175.1.196
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Funding
- Howard Hughes Medical Institute Funding Source: Medline
- NIAID NIH HHS [R01 AI043347-02, R01 AI019335-19, AI19335, R01 AI019335] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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CD8 alpha(+) dendritic cells (DCs) have been shown to be the principal DC subset involved in priming MHC class I-restricted CTL immunity to a variety of cytolytic viruses, including HSV type 1, influenza, and vaccinia virus. Whether priming of CTLs by CD8 alpha(+) DCs is limited to cytolytic viruses, which may provide dead cellular material for this DC subset, or whether these DCs selectively present intracellular Ags, is unknown. To address this question, we examined Ag presentation to a noncytolytic virus, lymphocytic choriomeningitis virus, and to an intracellular bacterium, Listeria monocytogenes. We show that regardless of the type of intracellular infection, CD8 alpha(+) DCs are the principal DC subset that initiate CD8(+) T cell immunity.
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