Journal
NEUROLOGICAL RESEARCH
Volume 27, Issue 5, Pages 516-521Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1179/174313213X13789811969265
Keywords
low-grade glioma; positron emission tomography; prognosis; time to progression
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Objectives: The aim of the present study was to assess the usefulness of positron emission tomography (PET) with the amino acid tracer C-11-methionine (MET) as a predictor of time to progression (TTP) in patients with supratentorial grade 2 gliomas. Methods: Twenty-seven patients with glioma grade 2 subjected to a baseline PET scan received no anti-tumour treatment except for a diagnostic operation, and were followed until tumour progression. The prognostic impact of the MET uptake and of other prognostic factors was studied. Results: Twenty-five of the patients (93 %) experienced tumour progression after a median of 103 weeks. Low uptake of MET was a predictor for long TTP in patients with oligodendrogliomas (p = 0.04) but not in astrocytomas/oligoastrocytomas. Other predictors for long TTP were oligodendroglioma histology (p = 0.009) and seizures as presenting symptom (p = 0.03). Favourable prognostic factors for overall survival were oligodendroglioma histology (p = 0.002) and good performance status (p = 0.03). Conclusions: PET MET has a definite role in the therapeutic management of grade 2 gliomas. However, for the optimal use of PET MET in the clinical management of these patients, histological subclassification of the tumour is required.
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