Journal
PHARMACOLOGY & THERAPEUTICS
Volume 107, Issue 1, Pages 44-58Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pharmthera.2005.01.004
Keywords
chemokine; G-protein coupled receptor; receptor antagonists; autoimmune diseased; multiple sclerosis; clinical trials
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Chemokines belong to a family of chemotactic cytokines that direct the migration of immune cells towards sites of inflammation. They mediate their biological effects by binding to cell surface receptors, which belong to the G protein-coupled receptor superfamily. Since chemokines and their receptors have been implicated in the pathophysiology of a number of autoinflammatory diseases, chemokine receptor antagonists could prove to be useful therapeutics to target these diseases. Here, we review the role of chemokines in autoimmunity, concentrating mainly on the chemokine receptors CCR1 and CCR5, and discuss the potential utility of antagonists that target these 2 receptors as they progress through the clinic. (c) 2005 Published by Elsevier Inc.
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