Journal
EUROPEAN JOURNAL OF NEUROSCIENCE
Volume 22, Issue 1, Pages 201-211Publisher
WILEY
DOI: 10.1111/j.1460-9568.2005.04209.x
Keywords
amygdala; fear conditioning; nitric oxide; plasticity; rat
Categories
Funding
- NIMH NIH HHS [MH 11902, MH 46516, MH 39774, MH 570161, MH 00956, MH 62519] Funding Source: Medline
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Nitric oxide (NO) has been widely implicated in synaptic plasticity and memory formation. In studies of long-term potentiation (LTP), NO is thought to serve as a 'retrograde messenger' that contributes to presynaptic aspects of LTP expression. In this study, we examined the role of NO signaling in Pavlovian fear conditioning. We first show that neuronal nitric oxide synthase is localized in the lateral nucleus of the amygdala (LA), a critical site of plasticity in fear conditioning. We next show that NO signaling is required for LTP at thalamic inputs to the LA and for the long-term consolidation of auditory fear conditioning. Collectively, the findings suggest that NO signaling is an important component of memory formation of auditory fear conditioning, possibly as a retrograde signal that participates in presynaptic aspects of plasticity in the LA.
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