Journal
NATURE IMMUNOLOGY
Volume 6, Issue 7, Pages 707-714Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1210
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Funding
- NIAID NIH HHS [R21 AI055037, AI055037, R01 AI055037, AI051573, P01 AI051573] Funding Source: Medline
- NIGMS NIH HHS [T32 GM007739, GM07739] Funding Source: Medline
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The maturation status of dendritic cells (DCs) determines whether they prime or tolerize T cells. We targeted ovalbumin peptide exclusively to DCs in situ using an antibody to DEC-205 and studied the interaction of DCs with naive CD4(+) T cells in tolerizing or priming conditions. We used two-photon microscopy to simultaneously track antigen-specific OT-II T cells, nonspecific T cells and DCs in lymph nodes of living mice. In both tolerance and immunity, OT-II cells arrested on DCs near high endothelial venules beginning shortly after extravasation and regained their baseline speed by 18 h. Thus, early antigen-dependent T cell arrest on DCs is a shared feature of tolerance and priming associated with activation and proliferation.
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