Journal
PEDIATRIC SURGERY INTERNATIONAL
Volume 21, Issue 7, Pages 578-581Publisher
SPRINGER
DOI: 10.1007/s00383-005-1451-4
Keywords
caudal regression syndrome; caudal dysplasia sequence; sacral agenesis; congenital malformations
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Caudal regression syndrome is a rare disorder of distal spinal segments affecting the development of the spinal cord, with attendant sequelae. Intelligence is preserved. The exact etiology is elusive, though maternal diabetes, genetic factors, and hypoperfusion might play roles. Recently, the role of teratogens has been studied in animal models. Treatment is difficult, multidisciplinary, and largely supportive. Lower limb deformities with sensory and motor loss and neurogenic bladder call for intensive and long-term attention.
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