Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 54, Issue 1, Pages 201-206Publisher
WILEY
DOI: 10.1002/mrm.20553
Keywords
magnetization transfer; spinal cord; cerebrospinal fluid; adrenomyeloneuropathy (AMN); MRI
Funding
- NCRR NIH HHS [5M01-RR000052-43] Funding Source: Medline
- NIBIB NIH HHS [P41 EB015909, EB00991-01] Funding Source: Medline
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The magnetization transfer ratio (MTR) is a reliable measure of MT effects because it employs an internal standard that allows quantitative comparison between subjects, independent of other contrasts, coil loading, and coil sensitivity profiles. However, at very high spatial resolution in the spinal cord at 1.5 T, the use of MTR quantification has been hampered by low signal-to-noise ratio (SNR) and acute sensitivity to motion. Here, the suitability of cerebrospinal fluid (CSF) as an alternative inter-subject MT signal intensity reference for the spine is evaluated. Contrary to MTR, this so-called MTCSF internal standard does not remove interfering T-1, T-2, and spin density contrast and is not expected to be able to discriminate between myelination and inflammation effects. However, it can detect initial changes in myelination when signal alterations are not yet detectable by conventional MRI. As a first example, this is demonstrated for the noninflammatory spinal cord white matter disease adrenomyeloneuropathy. (c) 2005 Wiley-Liss, Inc.
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