4.4 Article

α-Amylase: An Ideal Representative of Thermostable Enzymes

Journal

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
Volume 160, Issue 8, Pages 2401-2414

Publisher

SPRINGER
DOI: 10.1007/s12010-009-8735-4

Keywords

alpha-Amylase; Thermostability; Structural flexibility; Rigidity; Unfolding state

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The conditions prevailing in the industrial applications in which enzymes are used are rather extreme, especially with respect to temperature and pH. Therefore, there is a continuing demand to improve the stability of enzymes and to meet the requirements set by specific applications. In this respect, thermostable enzymes have been proposed to be industrially relevant. In this review, alpha-amylase, a well-established representative of thermostable enzymes, providing an attractive model for the investigation of the structural basis of thermostability of proteins, has been discussed.

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