Journal
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
Volume 158, Issue 2, Pages 476-482Publisher
HUMANA PRESS INC
DOI: 10.1007/s12010-009-8553-8
Keywords
Monascus; Lovastatin; Temperature-shift cultivation; Pigment; Citrinin
Funding
- Program for the Promotion of Industry-University-Government Joint Research in Okinawa,
- Okinawa Cutting-Edge Genome Project,
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Monascus pilosus NBRC4520 was selected for functional fermented food inoculation for its high lovastatin and low citrinin production with a deep-red color. For koji (mold rice) with high lovastatin production, separation of the growth phase and lovastatin production phase by shifting the temperature from 30 to 23 A degrees C increased lovastatin production by nearly 20 times compared to temperature-constant cultivation. In addition, citrinin was not produced even in the lovastatin production phase, although the pigment was increased. With temperature-shift cultivation, 225 mu g lovastatin/g dry koji was produced in 14 days without citrinin.
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