Journal
CHEMICAL ENGINEERING SCIENCE
Volume 60, Issue 14, Pages 3949-3957Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ces.2005.02.028
Keywords
solid dosage forms; agglomeration; extrusion; fluid bed; spray-drying; roller compaction
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Traditionally the manufacturing of pharmaceutical dosage forms has been a batch-wise process and continuous processes have limited applications in a pharmaceutical manufacturing plant. However, several factors (reduction of cost, improved process efficiency, optimal use of equipment, flexibility in production capacity) are stimulating the pharmaceutical industry to investigate the opportunities offered by continuous processes. This paper discusses some of the techniques which could be implemented in a continuous granulation process of pharmaceuticals. (c) 2005 Elsevier Ltd. All rights reserved.
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