Related references
Note: Only part of the references are listed.A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation
Gopinath Sutendra et al.
CELL (2014)
Dichloroacetate attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer through the regulation of glucose metabolism
Yi Xuan et al.
EXPERIMENTAL CELL RESEARCH (2014)
Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors
E. M. Dunbar et al.
INVESTIGATIONAL NEW DRUGS (2014)
Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer
Edward B. Garon et al.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2014)
A Phase II, Open-Label Study of Ramucirumab in Combination with Paclitaxel and Carboplatin as First-Line Therapy in Patients with Stage IIIB/IV Non-Small-Cell Lung Cancer
D. Ross Camidge et al.
JOURNAL OF THORACIC ONCOLOGY (2014)
Activating oxidative phosphorylation by a pyruvate dehydrogenase kinase inhibitor overcomes sorafenib resistance of hepatocellular carcinoma
Y-C Shen et al.
BRITISH JOURNAL OF CANCER (2013)
Dichloroacetate reverses the hypoxic adaptation to bevacizumab and enhances its antitumor effects in mouse xenografts
Krishan Kumar et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2013)
Long-term safety of dichloroacetate in congenital lactic acidosis
Monica Abdelmalak et al.
MOLECULAR GENETICS AND METABOLISM (2013)
Mitochondrial activation by inhibition of PDKII suppresses HIF1α signaling and angiogenesis in cancer
G. Sutendra et al.
ONCOGENE (2013)
Pyruvate dehydrogenase kinase as a novel therapeutic target in oncology
Gopinath Sutendra et al.
FRONTIERS IN ONCOLOGY (2013)
Human Polymorphisms in the Glutathione Transferase Zeta 1/Maleylacetoacetate Isomerase Gene Influence the Toxicokinetics of Dichloroacetate
Albert L. Shroads et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2012)
Combination of Sulindac and Dichloroacetate Kills Cancer Cells via Oxidative Damage
Kasirajan Ayyanathan et al.
PLOS ONE (2012)
Synergistic Antitumor Effect of Dichloroacetate in Combination with 5-Fluorouracil in Colorectal Cancer
Jingtao Tong et al.
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2011)
Tyrosine Phosphorylation of Mitochondrial Pyruvate Dehydrogenase Kinase 1 Is Important for Cancer Metabolism
Taro Hitosugi et al.
MOLECULAR CELL (2011)
Metabolic Modulation of Glioblastoma with Dichloroacetate
E. D. Michelakis et al.
SCIENCE TRANSLATIONAL MEDICINE (2010)
Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate
Shanta Dhar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Matthew G. Vander Heiden et al.
SCIENCE (2009)
Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation
Wengang Cao et al.
PROSTATE (2008)
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
Sebastien Bonnet et al.
CANCER CELL (2007)
Dichloroacetate causes reversible demyelination in vitro: potential mechanism for its neuropathic effect
Natalia Felitsyn et al.
JOURNAL OF NEUROCHEMISTRY (2007)
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
JW Kim et al.
CELL METABOLISM (2006)
Dichloroacetate causes toxic neuropathy in MELAS - A randomized, controlled clinical trial
P Kaufmann et al.
NEUROLOGY (2006)
The HIF pathway in cancer
PH Maxwell
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2005)
Probing the mechanism of inactivation of human pyruvate dehydrogenase by phosphorylation of three sites
LG Korotchkina et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
New guidelines to evaluate the response to treatment in solid tumors
F Duffaud et al.
BULLETIN DU CANCER (2000)
New guidelines to evaluate the response to treatment in solid Tumors
P Therasse et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2000)
Share Paper
