Journal
NATURE REVIEWS IMMUNOLOGY
Volume 5, Issue 7, Pages 571-577Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nri1636
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The pre-T-cell receptor (pre-TCR) has a crucial role in the normal development of a T cells. Different views have emerged concerning the structure and function of the pre-TCR. This molecular complex can be viewed as a variant of the alpha beta -TCR in which the pre-TCR alpha-chain that is covalently associated with the TCR beta-chain is a 'surrogate' TCR alpha-chain. Alternatively, the unique structure of the pre-TCR might be associated with a unique function, owing to evolutionary selection of a pre-TCR alpha-chain that has different capabilities from the TCR alpha-chain. As described here, I consider that experimental evidence favours the latter view.
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