Journal
FREE RADICAL BIOLOGY AND MEDICINE
Volume 39, Issue 1, Pages 91-97Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2005.02.025
Keywords
phytoestrogens; glutathione; superoxide dismutase; glutathione peroxidase; catalase; free radicals
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Uncontrolled production of reactive oxygen species contributes to the pathogenesis of diseases such as cancer and cardiovascular disorders. Olive oil exerts remarkable preventive effects on the development of these diseases, which may be due to the action of various components of the olive oil. In fact, several findings suggest that minor components, like phytosterols such as beta-sitosterol, are responsible, at least in part, for these beneficial effects. Our results show that beta-sitosterol reverts the impairment of the glutathione/oxidized glutathione ratio induced by phorbol esters in RAW 264.7 macrophage cultures. These data can be correlated with the increase in manganese superoxide dismutase and glutathione peroxidase activities and the decrease in catalase activity. We also demonstrate that the effects of beta-sitosterol on antioxidant enzymes depend on the estrogen/phosphatidylinositol 3-kinase pathway. (c) 2005 Elsevier Inc. All rights reserved.
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