Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 54, Issue 1, Pages 152-158Publisher
JOHN WILEY & SONS INC
DOI: 10.1002/mrm.20518
Keywords
spectroscopic imaging; narrow bandwidth; muscular lipids; fat; intramyocellular triglycerides
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A novel spectroscopic imaging method with high spectral and spatial resolution was developed for the specific goal of assessing muscle fat. Sensitivity to the methylene and methyl protons of fatty acids was improved by the use of a binomial 11 excitation pulse instead of the standard radiofrequency (RF) pulse. Acceptable measurement time is achieved by using a narrow spectral bandwidth (6 ppm). The spectral resolution is sufficient to resolve extramyocellular (EMCL) and intramyocellular (IMCL) lipids. A post-detection data processing scheme that permits correction of spectral artifacts caused by chemical shifts, spectral line aliasing, and magnetic field inhomogeneities is suggested. The lipid content in different lower leg muscles was evaluated. Muscle fiber orientation was taken into account in assessing quantities of EMCL and IMCL. The proposed technique allows small amounts of inhomogeneously distributed muscle lipids to be quantified. (c) 2005 Wiley-Liss, Inc.
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