Journal
GENETICS
Volume 170, Issue 3, Pages 1427-1430Publisher
GENETICS
DOI: 10.1534/genetics.105.040683
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A general MHC-heterozygote advantage in parasite-infected organisms is often assumed, although there is little experimental evidence for this. We tested the response of MHC-congenic mice (F-2 segregants) to malaria and found the course of infection to be significantly influenced by MHC haplotype, parasite strain, and host gender. However, the MHC heterozygotes did worse than expected from the average response of the homozygotes.
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