Journal
DEVELOPMENT
Volume 132, Issue 14, Pages 3281-3291Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.01891
Keywords
PTEN; Bergmann glia; cerebellar development; mouse
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Funding
- NCI NIH HHS [U01CA84128-06, R01CA107166] Funding Source: Medline
- NINDS NIH HHS [NS38439] Funding Source: Medline
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Development of the central nervous system is controlled by both intrinsic and extrinsic signals that guide neuronal migration to form laminae. Although defects in neuronal mobility have been well documented as a mechanism for abnormal laminar formation, the role of radial glia, which provide the environmental cues, in modulating neuronal migration is less clear. We provide evidence that loss of PTEN in Bergmann glia leads to premature differentiation of this crucial cell population and subsequently to extensive layering defects. Accordingly, severe granule neuron migration defects and abnormal laminar formation are observed. These results uncover an unexpected role for PTEN in regulating Bergmann glia differentiation, as well as the importance of time-dependent Bergmann glia differentiation during cerebellar development.
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