Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 202, Issue 1, Pages 123-133Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20050137
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Funding
- NHLBI NIH HHS [P01 HL063925, HL63925] Funding Source: Medline
- NIAID NIH HHS [AO055500, AI58668, F32 AI058668, R01 AI055500] Funding Source: Medline
- NIA NIH HHS [P01 AG021600, AG021600] Funding Source: Medline
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Although the absolute number of memory CD8(+) T cells established in the spleen following antigen encounter remains stable for many years, the relative capacity of these cells to mediate recall responses is not known. Here we used a dual adoptive transfer approach to demonstrate a progressive increase in the quality of memory T cell pools in terms of their ability to proliferate and accumulate at effector sites in response to secondary pathogen challenge. This temporal increase in efficacy occurred in CD62L(lo) (effector memory) and CD62L(hi) (central memory) subpopulations, but was most prominent in the CD62L(hi) subpopulation. These data indicate that the contribution of effector memory and central memory T cells to the recall response changes substantially over time.
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