4.0 Article

Enantioselective synthesis of (2R,3R)- and (2S,3S)-2-[(3-chlorophenyl)-(2-methoxyphenoxy)methyl]morpholine

Journal

TETRAHEDRON-ASYMMETRY
Volume 16, Issue 13, Pages 2249-2256

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetasy.2005.06.012

Keywords

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Funding

  1. NIDA NIH HHS [K05 DA015343-04, K05 DA015343] Funding Source: Medline

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The enantioselective synthesis of the (R,R)- and (S,S)-enantiorners of 1 from cominercially available 3-chlorocinnamic acid is reported. The Sharpless asymmetric epoxidation was used to establish the stereocenters in the synthesis of both enantioiners of 1. (c) 2005 Elsevier Ltd. All rights reserved.

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