Journal
FEBS LETTERS
Volume 579, Issue 17, Pages 3821-3828Publisher
WILEY
DOI: 10.1016/j.febslet.2005.05.079
Keywords
axon guidance; hippocampus synapse; semaphorin
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The semaphorins are a large family of proteins that act as guidance signals for axons and dendrites. The class 4 semaphorins are integral membrane proteins that are widely expressed throughout the nervous system. Here, we show that a subclass of these semaphorins is characterized by a PDZ-binding motif at their carboxy-terminus. This sequence mediates the interaction with the post-synaptic density protein PSD-95/SAP90. Co-expression of Sema4B with PSD-95 in COS 7 cells results in the clustering of Sema4B. Sema4B co-localizes with PSD-95 at synaptic contacts between cultured hippocampal neurons. This synaptic localization depends on the presence of the PDZ-binding motif. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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