Journal
NEW ENGLAND JOURNAL OF MEDICINE
Volume 353, Issue 1, Pages 58-63Publisher
MASSACHUSETTS MEDICAL SOC
DOI: 10.1056/NEJMoa043157
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Monozygotic 24-year-old twins presented with discordant ovarian function. One had premature ovarian failure at the age of 14 years, whereas her sister had normal ovaries and three naturally conceived children. After unsuccessful egg-donation therapy, the sterile twin received a transplant of ovarian cortical tissue from her sister by means of a minilaparotomy. Within three months after transplantation, the recipient's cycles resumed and serum gonadotropin levels fell to the normal range. During the second cycle, she conceived, and her pregnancy progressed uneventfully. At 38 weeks' gestation, she delivered a healthy-appearing female infant.
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