Journal
ORGANIC LETTERS
Volume 7, Issue 14, Pages 2965-2967Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol050891l
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A gram-scale approach toward (-)-epibatidine (1, naturally occurring enantiomer), a novel class of amphibian alkaloid, has been developed from readily available starting materials using mild and easily controlled reactions. The entire synthetic route is straightforward and convenient for gram-scale synthesis.
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