Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1744, Issue 3, Pages 455-464Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2005.04.007
Keywords
protein trafficking; polarized secretion; sorting signal; Golgi complex; default pathway
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Funding
- NEI NIH HHS [R01 EY008538] Funding Source: Medline
- NIGMS NIH HHS [R01 GM034107] Funding Source: Medline
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The paradigms for transport along the biosynthetic route have changed dramatically over the past 15 years. Unlike the situation 15 years ago, the current paradigm involves sorting signals practically at every step of the pathway. In particular, at the exit from the Golgi complex, apical, basolateral and lysosomal targeting signals result in the generation of a variety of routes. Furthermore, it is now quite clear that not all sorting in the biosynthetic route occurs in the Golgi complex or the Trans Golgi Network (TGN). Sorting may occur distally to the Golgi, in recycling endosomes or in budded tubulosaccular structures, or it may occur proximally to the Golgi complex, at the exit from the ER. Several adaptors are candidates to sort apical and basolateral proteins but only AP1B and AP4 are currently involved. Progress is fast and future work should elucidate many of the open questions. (c) 2005 Elsevier B.V. All rights reserved.
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