Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1744, Issue 3, Pages 438-454Publisher
ELSEVIER
DOI: 10.1016/j.bbamcr.2005.04.004
Keywords
vacuole protein sorting (VPS); late golgi; multivesicular body (MVB); endosome; protein trafficking; yeast
Categories
Funding
- NIGMS NIH HHS [GM32448, GM38006] Funding Source: Medline
Ask authors/readers for more resources
The late Golgi compartment is a major protein sorting station in the cell. Secreted proteins, cell surface proteins, and proteins destined for endosomes or lysosomes must be sorted from one another at this compartment and targeted to their correct destinations. The molecular details of protein trafficking pathways from the late Golgi to the endosomal system are becoming increasingly well understood due in part to information obtained by genetic analysis of yeast. It is now clear that proteins identified in yeast have functional homologues (orthologues) in higher organisms. We will review the molecular mechanisms of protein targeting from the late Golgi to endosomes and to the vacuole (the equivalent of the mammalian lysosome) of the budding yeast Saccharom-wes cerevisiae. (c) 2005 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available