Journal
JOURNAL OF NEUROSCIENCE
Volume 25, Issue 28, Pages 6509-6519Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1211-05.2005
Keywords
anxiety; theta rhythm; knock-out; 5-HT1A receptor; ripple oscillations; awake behaving recording
Categories
Funding
- NIMH NIH HHS [P01 MH48125, K08 MH 069823] Funding Source: Medline
Ask authors/readers for more resources
Mice lacking the serotonin 1A receptor (5-HT1AR) show increased levels of anxiety-related behavior across multiple tests and background strains. Tissue-specific rescue experiments, lesion studies, and neurophysiological findings all point toward the hippocampus as a potential mediator of the phenotype. Serotonin, acting through 5-HT(1A)Rs, can suppress hippocampal theta-frequency oscillations, suggesting that theta oscillations might be increased in the knock-outs. To test this hypothesis, local field potential recordings were obtained from the hippocampus of awake, behaving knock-outs and wild-type littermates. The magnitude of theta oscillations was increased in the knock-outs, specifically in the anxiety-provoking elevated plus maze and not in a familiar environment or during rapid eye movement sleep. Theta power correlated with the fraction of time spent in the open arms, an anxiety-related behavioral variable. These results suggest a possible role for the hippocampus, and theta oscillations in particular, in the expression of anxiety in 5-HT1AR-deficient mice.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available