Journal
MACROMOLECULAR BIOSCIENCE
Volume 5, Issue 7, Pages 629-635Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200500029
Keywords
bioerodible; gelation; injectable; PNIPAAm; stimuli-sensitive polymers
Funding
- NIGMS NIH HHS [5R01 GM065917-02, R01 GM065917] Funding Source: Medline
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Copolymers of N-isopropylacrylamide, 2-hydroxyethyl methacryl lactate [(HEMA)-lactate] and acrylic acid (AAc) were prepared with varying mole ratios of monomers to develop copolymers with gelation properties above a certain concentration for a bioerodible, in-situ gelling material. The copolymers formed gels in situ under physiological condition. The gelation temperature of the copolymers decreased as the HEMA-lactate content of the copolymers increased due to the hydrophobicity of HEMA-lactate, and increased as the AAc content increased due to the hydrophilicity of AAc. The gels redissolve at 37 degrees C as their LCSTs increase above 37 degrees C due to the hydrolysis of the HEMA-lactate pendant groups.
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