Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 99, Issue 3, Pages 353-360Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2005.01.040
Keywords
antimutagenicity; cytotoxicity; cancer cells; acacia nilotica; salmonella typhimurium
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The present study was undertaken to evaluate antimutagenic and cytotoxic effects of different extracts/fractions of Acacia nilotica prepared by maceration method. The potency order of different extracts was more or less similar in Ames assay as well as in cytotoxic assay. Considering the maximum potential of acetone extract in both the assays, the studies were initiated to fractionate this extract. Two pure fractions, namely AN-1 and AN-2, were obtained from acetone extract, of which AN-2 was found to be of gallic acid and AN-1 fraction is still to be identified. In conclusion, the antimutagenic and cytotoxic activities exhibited by acetone extract may partially be ascribed to the presence of gallic acid and other polyphenols. (c) 2005 Published by Elsevier Ireland Ltd.
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