Journal
DEVELOPMENTAL BIOLOGY
Volume 283, Issue 2, Pages 269-281Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2005.03.040
Keywords
neural stem cells; neural progenitor cells; LeX; CD15; gene expression analysis
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Funding
- NINDS NIH HHS [NS033529, 5F32NS043081] Funding Source: Medline
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Neural progenitor cells can be derived from a variety of developmental stages when they are preferentially proliferating, undergoing neurogenesis or undergoing gliogenesis. We used FACS sorting and the LeX surface marker to enrich neural progenitor cells from different embryonic stages and adult and compared their gene expression profiles using Affymetrix Microarrays. Our results show that, while there are common genes expressed in the progenitor cell population from all stages, there are also significant differences in gene expression patterns that correlate with stage-related behaviors. These data indicate that progenitor cells change during development and that adult and embryonic neural progenitor cells are intrinsically different. (c) 2005 Elsevier Inc. All rights reserved.
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