Journal
DEVELOPMENTAL BIOLOGY
Volume 283, Issue 2, Pages 335-344Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2005.04.027
Keywords
BMP; Drm/Gremlin; chicken neuroretina; retinal lamination; optic nerve; Dan; N-cadherin
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During eye development, bone morphogenetic proteins (BMPs) exert multiple actions on both early and late patterning and differentiation processes. However, the roles of BMP signaling in retinal differentiation are not well understood. To gain insight into a novel role of BMPs during retinal development, we proceeded to retrovirally directed misexpression of the BMP antagonist Drm/Gremlin in the chicken optic vesicle. This resulted in severe eye defects, characterized by microphthalmia, coloboma and the presence of dark streaks. The latter phenotype corresponds to localized perturbations of the stratified structure of the neuroretina. We show that these retinal disorganizations are characterized by a destruction of neuronal layers associated with axonal pathfinding defects, increased apoptosis and lost of N-cadherin expression. Moreover, whereas neuronal differentiation seems to proceed normally, Muller glial differentiation is impaired in Drm-induced disorganizations. These data suggest a possible role of BMP signaling in the laminar organization of the developing neuroretina. (c) 2005 Elsevier Inc. All rights reserved.
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