Journal
SCHIZOPHRENIA RESEARCH
Volume 76, Issue 2-3, Pages 199-206Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2005.01.021
Keywords
schizophrenia; major depression; context processing; prefrontal cortex; functional MRI; hypofrontality
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Funding
- NIMH NIH HHS [T32 MH18269, MH47073, MH59883] Funding Source: Medline
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Patients with schizophrenia frequently demonstrate hypofrontality in tasks that require executive processing; however questions still remain as to whether prefrontal cortex dysfunctions are specific to schizophrenia, or a general feature of major psychopathology. Context processing is conceptualized as an executive function associated with attention and working memory processes. Impairment in the ability of patients with schizophrenia to represent and maintain context information has been previously reported in a number of studies. To examine the question of the specificity of a context processing deficit to schizophrenia, we used functional MRI and an expectancy AX continuous performance task designed to assess context processing in a group of healthy controls (n=9), depressed patient controls (n=10), and patients with schizophrenia (n=7). The behavioral performance was consistent with a context processing deficit in patients with schizophrenia, but not those with depression. The imaging data replicate previous results in showing abnormal activity in the right middle frontal gyrus (BA9) in schizophrenia patients related to context processing. (c) 2005 Published by Elsevier B.V.
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