Journal
JOURNAL OF IMMUNOLOGY
Volume 175, Issue 2, Pages 977-984Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.175.2.977
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Funding
- NCI NIH HHS [CA 58896] Funding Source: Medline
- NIAID NIH HHS [AI 45053] Funding Source: Medline
- NIGMS NIH HHS [GM 62116] Funding Source: Medline
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NKT cells are immunoregulatory lymphocytes whose activation is triggered by the recognition of lipid Ags in the context of the CD1d molecules by the TCR. In this study we present the crystal structure to 2.8 angstrom of mouse CD1d bound to phosphatidylcholine. The interactions between the ligand acyl chains and the CD1d molecule define the structural and chemical requirements for the binding of lipid Ags to CD1d. The orientation of the polar headgroup toward the C terminus of the alpha 1 helix provides a rationale for the structural basis for the observed V alpha chain bias in invariant NKT cells. The contribution of the ligand to the protein surface suggests a likely mode of recognition of lipid Ags by the NKT cell TCR.
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