4.7 Article

N,N′-Bis(3-aminopropyl)-2,7-diamino-1,8-naphthyridine stabilized a single pyrimidine bulge in duplex DNA

Journal

BIOORGANIC & MEDICINAL CHEMISTRY
Volume 13, Issue 14, Pages 4507-4512

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2005.04.035

Keywords

cytosine; bulge; CSI-TOF; DNA

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We here show the first identified ligand 2,7-diamino-1,8-naphthyridine (DANP) that strongly and specifically binds to the single cytosine and thymine bulges with exclusively 1:1 stoichiometry. (c) 2005 Elsevier Ltd. All rights reserved.

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