Journal
NEUROSCIENCE LETTERS
Volume 382, Issue 3, Pages 346-351Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2005.03.024
Keywords
ApoE; event-related potentials; mild cognitive impairment; N1; N2
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Identification of biological or cognitive changes in brain function, associated with allelic variation in Apolipoprotein E, is important for unravelling the mechanism behind the increased risk for Alzheimer's disease associated with the epsilon 4 allele. Cognitive event-related potentials (ERPs) show high degrees of heritability and are sensitive to subtle cognitive deficits. They may, therefore, be good candidates for assessing allelic effects. Non-demented patients age 50-76 undergoing investigation for memory problems performed ERP paradigms for testing automatic (MMN) and cognitive (N1, N2, P3) attention functions. The results indicated attenuation in the amplitude of the N1 and N2 ERP components depending on the dose of the e4 allele. Findings are consistent with studies showing reduced fronto-temporal metabolic activity in ApoE4 carriers. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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