Pallado-catalysed P-arylations and P-anylation of 2-hydrogeno-2-oxo-1,4,2-oxazaphosphinanes

A simple and effective preparation of 2-aryl-(or 2-vinyl)-1,4,2-oxazaphosphines. phosphorus analogues of aryl-morpholinols has been developed. involving palladium catalysed coupling of aryl (or vinyl)-halides with 2-H-1,4,2-oxazaphosphinane in presence of triethylamine. A deprotection step was also proposed to afford the corresponding P-aryl-alpha-aminobenzylphosphinic acid. (c) 2005 Elsevier Ltd. All rights reserved.