Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 202, Issue 2, Pages 203-207Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20050810
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Funding
- NCI NIH HHS [R01 CA108609, R01CA108609, P01 CA084512, P01CA84512] Funding Source: Medline
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Pathogen recognition by Toll-like receptors (TLRs) on dendritic cells (DCs) leads to DC maturation and the initiation of adaptive immunity. Recent studies have shown that innate lymphocytes-natural killer (NK), natural killer T (NKT), and gamma delta T cells - also trigger DC maturation. This interaction in turn expands and activates innate lymphocytes and initiates adaptive T cell immunity. Here, we comment on the evidence that these pathways are TLR independent and have the potential to respond to infection, malignancy, and immunotherapy.
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