Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 102, Issue 29, Pages 10094-10098Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0503017102
Keywords
elongation; mRNA synthesis; transcription; transcription factor
Categories
Funding
- NIGMS NIH HHS [R37 GM41628, R37 GM041628] Funding Source: Medline
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In human cells, the ELL family of transcription factors includes at least three members, which are all capable of stimulating the overall rate of elongation by RNA polymerase II by suppressing transient pausing by the enzyme at many sites along DNA. In this report, we identify the ELL-associated factors (EAF)1 and EAF2 as strong positive regulators of ELL elongation activity. Our findings provide insights into the structure and function of ELL family transcription factors, and they bring to light direct roles for the EAF proteins in regulation of RNA polymerase 11 transcription.
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